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Sirius’s protein crystallography beamline analyzed more than 200 protein crystals from the novel coronavirus as they were exposed to tiny fragments of widely used drugs. If a compound fits perfectly into a target protein, its action can be blocked in the virus.

Devices developed by Brazilian startup BioLambda decontaminate face shields, surfaces, workspaces and air.

Intervention was tested in mice by Brazilian researchers. Study showed that targeted stimulation of PKA production promoted muscle growth and enhanced resistance to fatigue.

Investigation conducted by international group of researchers showed that chikungunya virus can cause neurological infections. Risk of death in subacute phase is higher for patients with diabetes and significant for young adults.

Three waves of the disease swept the state between 2016 and 2018. An international group of researchers described how the virus spread in a study published in PLOS Pathogens based on the sequencing of 51 viral isolates extracted from mosquitoes and monkeys.

Brazilian researchers discovered that sTREM-1 protein in immunoglobulin family could be a very useful biomarker to help medical teams make clinical decisions.

Experiments conducted by Brazilian researchers with lymphocytes isolated from COVID-19 patients showed the virus using the protein CD4 to invade cells that play a key role in coordinating the immune response.

Analyses by Brazilian researchers suggest alterations to pH caused by stomach acid lead to increase in expression of ACE2 and make cells more susceptible to infection by novel coronavirus.

The newest Engineering Research Center will initially focus on challenges relating to health, the environment, food production chains, the future of work, and the development of natural language processing tools for Brazilian Portuguese.

Renowned scientists will address topics related to how society has been coping with this threatening environment and will discuss factors that influence behavioral change.

Adaptation of muscle tissue to aerobic exercise alters the metabolism of muscle stem cells, helping them recover from injury. Findings may contribute to treatment of cachexia, sarcopenia and other conditions associated with lean mass loss.

Findings reported by Brazilian researchers in PLOS Neglected Tropical Diseases help explain why only some babies whose mothers are infected during pregnancy are born with microcephaly and other anomalies.

Analysis identified 525 genes encoding proteins that act on the nervous system, cardiovascular system and cell walls. One of the molecules proved effective against cancer cells in preliminary test results.

Led by research groups from the universities of Campinas and São Paulo, the investigation combined MRI scans of mild COVID-19 patients, analysis of brain tissue samples from patients who died from COVID-19, and experiments performed with human nerve cells infected in the laboratory.

Brazilian researchers found the novel coronavirus replicating inside immune cells from patients hospitalized with COVID-19. Experiments on lymphocytes infected in the laboratory showed that viral entry induced programmed cell death.

A study quantified the size and age of the forests that grow naturally in degraded and abandoned areas, creating 131 benchmark maps for Brazil. The Amazon has the most restored forests and the Atlantic Rainforest biome has the oldest.

In an article published in the Journal of Experimental Medicine, a group affiliated with a FAPESP-supported research center reports that an enzyme associated with energy production in cells also participates in the differentiation of immune cells involved in exacerbated inflammation. The discovery could lead to more effective treatment.

Study by Brazilian and South African researchers is the first to prove, using a graph analysis tool, that REM dream narratives tend to be more complex and connected than reports of non-REM dreams

Brazilian startup Agrobee signs agreement with Agroven, an investment club run by family farmers who want to promote technological development in the sector.

Conclusion presented by Brazilian researchers in Obesity Research & Clinical Practice is based on analysis of nine clinical studies involving 6,577 patients infected by SARS-CoV-2 in five countries.

Methodology developed by Brazilian researchers is based on analysis of metabolites in blood serum. Innovation has been patented and reported in Journal of Psychiatric Research.

Study led by researchers at Oxford University suggests that after successive infections by the coronaviruses that cause common colds throughout life the defense system becomes specialized and cannot recognize emergent varieties such as SARS-CoV-2.

Study conducted at São Paulo State University demonstrates for first time that simple and inexpensive strategy yields better results than conventional treatment and avoids indiscriminate use of antibiotics.

Laboratory tests showed film containing silver-silica nanoparticles to be capable of eliminating 99.84% of SARS-CoV-2 particles after exposure for two minutes.

Study correlated confirmed and suspected COVID-19 deaths in the city of São Paulo between March and June with socio-economic data on area in which deceased patients lived, showing that such deaths peaked in mid-May.

Simulations using field data suggest focusing on the protection of species that live in rivers and lakes can be more efficient than the approach most used now, which focuses on terrestrial biodiversity. An article at Science is based on the findings.

A cross-border group led by researchers at the University of São Paulo presented findings for Manaus from a study based on mathematical modeling combined with serological analysis. The results showed seroprevalence at 22% in the city of São Paulo.

Brazilian researchers studied the morphology of owl wings in search of characteristics that enable these birds to fly silently.

An article in The Lancet stresses the vulnerability of these health workers, whose readiness to counter fake news with trustworthy information, and to monitor COVID-19 patients in home isolation, has been neglected.

Model developed by Brazilian researchers predicts spatial and temporal evolution of epidemic diseases and can help plan more effective social isolation programs with less socio-economic impact.

Collaborative projects in these knowledge areas can produce information that helps policymakers understand the behavioral changes required to manage the ongoing public health crisis and mitigate its impacts, according to participants in the annual meeting of the Trans-Atlantic Platform, held online in September.

In the fourth phase of EPICOVID-19 BR, the proportion of the population with antibodies against the novel coronavirus fell from 3.8% in June to 1.4% in August in 133 cities. According to the authors, the methodology accurately estimates contagion rates in the previous 45 days.

Brazilian researchers show that African forage grasses resist management by fire and that palisade grass tends to spread to burned areas previously occupied by molasses grass, another invasive species.

Brazilian researchers discover that caecilians, limbless amphibians resembling worms or snakes that emerged some 150 million years before the latter, can probably inject venom into their prey while biting.

Brazilian research group shows that valproic acid (VPA), used to treat epilepsy since the 1960s, modulates gene expression in tumor gene models and acts on DNA conformation and the histones in chromatin.

Protocol developed by Brazilian researchers shows SARS-CoV-2 replicating near cell nucleus. Methodology helps scientists understand coronavirus’s action mechanism and could also be used to study other viruses.

Portable nuclear magnetic resonance device designed with FAPESP’s support will inform consumers regarding value added to beef products.

Analysis published in Scientific Reports is based on climate models for the mid-Pliocene period, which occurred 3 million years ago and shared characteristics with present-day warming.

Researchers affiliated with institutions in Brazil and elsewhere analyzed blood work from almost 179,000 people who were tested for the novel coronavirus. They obtained the data from COVID-19 Data Sharing/BR, an open-access repository established by FAPESP.

Brazilian researchers’ finding that exercising in the evening reduces blood pressure more than in the morning can help health professionals choose the time of day for aerobic training depending on the type of anti-hypertensive drug they take.

Researchers from six countries in the Americas explored bromeliad microcosms, showing how drought and flood affect the functioning of aquatic ecosystems, especially at the bottom of the food chain.

New research field promises to transform food production and treatment of diseases. A global panel of experts unified concepts to define research priorities and offer basis for legislation.

The startup’s founders were researchers at the University of São Paulo and adjusted their marketing strategy to focus on regenerative, veterinary and sports medicine thanks to training provided by PIPE, FAPESP’s program for Innovative Research in Small Business.

Designed by the Human Genome and Stem Cell Research Center, the novel test may cost a quarter of those based on RT-PCR, considered the gold standard for diagnosis of the disease.

Integrated with the air quality management tool created by startup Omni-electronica, a collector captures viruses suspended in the environment and submits the air samples to RT-PCR testing. Monitoring of crowded locations combined with indicators created by the firm can contribute to a safer economic reopening.

Dozens of scientists from several countries calculated upper limits to global and local temperatures if tropical forests are to survive.

Project led by researchers from Brazilian and American institutions will collect primary data during the pandemic to create a repository that will serve as a basis for future studies. The findings of the comparative analysis will be published in book form.

Economists who took part in a webinar organized by FAPESP to discuss options for the post-pandemic economic recovery said this is the right time to implement broad basic income policies.

Brazilian researchers use complex training program to stimulate different motor and cognitive skills simultaneously and restore brain regions associated with freezing of gait in advanced-stage patients.

Toxic protein inhibits cell wall synthesis in rival bacteria. Discovery helps explain how pathogens cause imbalances in established microbial communities and could pave the way to the development of novel anti-microbial compounds.